TRPM6

TRPM6
Identifiers
Aliases	TRPM6, CHAK2, HMGX, HOMG, HOMG1, HSH, transient receptor potential cation channel subfamily M member 6
External IDs	OMIM: 607009; MGI: 2675603; HomoloGene: 9767; GeneCards: TRPM6; OMA:TRPM6 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	74,888,094 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	18,869,875 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; rectum; ; hair follicle; ; duodenum; ; corpus callosum; ; blood; ; retinal pigment epithelium; ; bone marrow cells; ; lower lobe of lung; ; inferior ganglion of vagus nerve;
	Top expressed in
	conjunctival fornix; ; left colon; ; spermatid; ; right lung lobe; ; seminiferous tubule; ; oocyte; ; secondary oocyte; ; Paneth cell; ; yolk sac; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; ion channel activity; protein binding; cation channel activity; ATP binding; calcium channel activity;
Cellular component	integral component of membrane; membrane; plasma membrane; brush border membrane; apical plasma membrane;
Biological process	phosphorylation; metal ion transport; cation transport; ion transport; protein tetramerization; protein phosphorylation; calcium ion transmembrane transport; response to toxic substance; calcium ion transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	140803
	225997
	ENSG00000119121
	ENSMUSG00000024727
	Q9BX84
	Q8CIR4
	NM_001177310; NM_001177311; NM_017662
	NM_153417
	NP_001170781; NP_001170782; NP_060132
	NP_700466
	Wikidata
View/Edit Human	View/Edit Mouse

TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119121 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024727 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schlingmann KP, Weber S, Peters M, et al. (2002). "Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family". Nat. Genet. 31 (2): 166–70. doi:10.1038/ng889. PMID 12032568. S2CID 40990544.

External links

TRPM6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119121 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024727 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Schlingmann KP, Weber S, Peters M, et al. (2002). "Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family". Nat. Genet. 31 (2): 166–70. doi:10.1038/ng889. PMID 12032568. S2CID 40990544.

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TRPM6

See also

References

Further reading

External links