KCNK1

KCNK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UKM
Identifiers
Aliases	KCNK1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1, potassium two pore domain channel subfamily K member 1
External IDs	OMIM: 601745; MGI: 109322; HomoloGene: 1691; GeneCards: KCNK1; OMA:KCNK1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	233,672,514 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	126,757,424 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; pons; ; endothelial cell; ; cerebellar hemisphere; ; orbitofrontal cortex; ; right hemisphere of cerebellum; ; paraflocculus of cerebellum; ; cartilage tissue; ; corpus epididymis; ; cardiac muscle tissue of right atrium;
	Top expressed in
	seminal vesicula; ; molar; ; mucosa of urinary bladder; ; cerebellar vermis; ; submandibular gland; ; pontine nuclei; ; Paneth cell; ; medial vestibular nucleus; ; crypt of lieberkuhn of small intestine; ; anterior horn of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	sodium channel activity; potassium ion leak channel activity; voltage-gated potassium channel activity; inward rectifier potassium channel activity; potassium channel activity; protein binding; identical protein binding;
Cellular component	cytoplasm; integral component of membrane; recycling endosome; perikaryon; endosome; cell projection; membrane; voltage-gated potassium channel complex; plasma membrane; integral component of plasma membrane; synapse; inward rectifier potassium channel complex; brush border membrane; cell junction; dendrite; potassium channel complex; apical plasma membrane; cytoplasmic vesicle; intracellular membrane-bounded organelle;
Biological process	sodium ion transmembrane transport; response to nicotine; ion transport; potassium ion transport; cardiac conduction; potassium ion transmembrane transport; regulation of resting membrane potential; stabilization of membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	3775
	16525
	ENSG00000135750
	ENSMUSG00000033998
	O00180
	O08581
	NM_002245
	NM_008430
	NP_002236
	NP_032456
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.^[5]^[6]^[7]

This gene encodes K_2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135750 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033998 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M (Dec 1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43". Genomics. 34 (1): 153–5. doi:10.1006/geno.1996.0259. PMID 8661042.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ ^a ^b "Entrez Gene: KCNK1 potassium channel, subfamily K, member 1".

External links

KCNK1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135750 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033998 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8661042-5] Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M (Dec 1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43". Genomics. 34 (1): 153–5. doi:10.1006/geno.1996.0259. PMID 8661042.

[pmid16382106-6] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[entrez-7] "Entrez Gene: KCNK1 potassium channel, subfamily K, member 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

KCNK1

See also

References

Further reading

External links