KCNQ4

KCNQ4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OVC, 4GOW
Identifiers
Aliases	KCNQ4, DFNA2, DFNA2A, KV7.4, potassium voltage-gated channel subfamily Q member 4
External IDs	OMIM: 603537; MGI: 1926803; HomoloGene: 78107; GeneCards: KCNQ4; OMA:KCNQ4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	40,840,452 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	120,605,809 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; muscle layer of sigmoid colon; ; right coronary artery; ; gastric mucosa; ; parotid gland; ; popliteal artery; ; tibial arteries; ; thoracic aorta; ; ascending aorta; ; left coronary artery;
	Top expressed in
	digastric muscle; ; lumbar spinal ganglion; ; extraocular muscle; ; muscle of thigh; ; knee joint; ; retinal pigment epithelium; ; temporal muscle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; thoracic diaphragm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; voltage-gated ion channel activity; ion channel activity; protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; calmodulin binding;
Cellular component	integral component of membrane; membrane; voltage-gated potassium channel complex; plasma membrane; basal plasma membrane;
Biological process	regulation of ion transmembrane transport; ion transport; hearing; potassium ion transport; transmembrane transport; potassium ion transmembrane transport; inner ear morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	9132
	60613
	ENSG00000117013
	ENSMUSG00000028631
	P56696
	Q9JK97
	NM_004700; NM_172163
	NM_001081142
	NP_004691; NP_751895
	NP_001074611
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily KQT member 4, also known as voltage-gated potassium channel subunit K_v7.4, is a protein that in humans is encoded by the KCNQ4 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene.^[7]

Clinical significance

The current generated by this channel is inhibited by muscarinic acetylcholine receptor M1 and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Ligands

ML213: KCNQ2/Q4 channel opener.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117013 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028631 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, El-Amraoui A, Marlin S, Petit C, Jentsch TJ (Mar 1999). "KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness". Cell. 96 (3): 437–46. doi:10.1016/S0092-8674(00)80556-5. PMID 10025409.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b ^c "Entrez Gene: KCNQ4 potassium voltage-gated channel, KQT-like subfamily, member 4".
^ Yu H, Wu M, Townsend SD, et al. (2011). "Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener". ACS Chem Neurosci. 2 (10): 572–577. doi:10.1021/cn200065b. PMC 3223964. PMID 22125664.

External links

GeneReviews/NCBI/NIH/UW entry on Deafness and Hereditary Hearing Loss Overview
KCNQ4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
GeneReviews/NCBI/NIH/UW entry on DFNA2 Nonsyndromic Hearing Loss

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117013 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028631 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10025409-5] Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, El-Amraoui A, Marlin S, Petit C, Jentsch TJ (Mar 1999). "KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness". Cell. 96 (3): 437–46. doi:10.1016/S0092-8674(00)80556-5. PMID 10025409.

[pmid16382104-6] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[entrez-7] "Entrez Gene: KCNQ4 potassium voltage-gated channel, KQT-like subfamily, member 4".

[pmid22125664-8] Yu H, Wu M, Townsend SD, et al. (2011). "Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener". ACS Chem Neurosci. 2 (10): 572–577. doi:10.1021/cn200065b. PMC 3223964. PMID 22125664.

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