Phosphosulfolactate synthase
| phosphosulfolactate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.4.1.19 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme phosphosulfolactate synthase (EC 4.4.1.19) catalyzes the reaction
- (2R)-2-O-phospho-3-sulfolactate phosphoenolpyruvate + sulfite
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is (2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming). Other names in common use include (2R)-phospho-3-sulfolactate synthase, and (2R)-O-phospho-3-sulfolactate sulfo-lyase.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U83.
References
- Graham DE, Xu H, White RH (2002). "Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes". J. Biol. Chem. 277 (16): 13421–9. doi:10.1074/jbc.M201011200. PMID 11830598.
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