FHL3

FHL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WYH, 2CUQ, 2EHE
Identifiers
Aliases	FHL3, SLIM2, four and a half LIM domains 3
External IDs	OMIM: 602790; MGI: 1341092; HomoloGene: 37928; GeneCards: FHL3; OMA:FHL3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	38,005,606 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,602,404 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; vastus lateralis muscle; ; thoracic diaphragm; ; triceps brachii muscle; ; deltoid muscle; ; tibialis anterior muscle; ; left uterine tube; ; ascending aorta; ; popliteal artery; ; right coronary artery;
	Top expressed in
	lip; ; esophagus; ; yolk sac; ; urethra; ; skeletal muscle tissue; ; male urethra; ; morula; ; aortic valve; ; thymus; ; quadriceps femoris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; metal ion binding;
Cellular component	Z disc; nucleus; stress fiber; focal adhesion;
Biological process	muscle organ development; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	2275
	14201
	ENSG00000183386
	ENSMUSG00000032643
	Q13643; Q96C98
	Q9R059
	NM_004468; NM_001243878
	NM_010213
	NP_001230807; NP_004459; NP_001230807.1
	NP_034343
	Wikidata
View/Edit Human	View/Edit Mouse

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.^[5]^[6]^[7]

LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.^[7]

Function

FHL3 plays a role in myogenesis,^[8] and also stimulates the development of neural crest by enhancing BMP signaling.^[9]

Interactions

FHL3 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183386 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032643 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem Biophys Res Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811.
^ Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999). "Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1". Somat Cell Mol Genet. 24 (3): 197–202. doi:10.1023/B:SCAM.0000007122.03392.4b. PMID 10226657. S2CID 40511123.
^ ^a ^b "Entrez Gene: FHL3 four and a half LIM domains 3".
^ Cottle et al., J Cell Sci. 2007 Apr 15;120(Pt 8):1423-35. doi: 10.1242/jcs.004739
^ Intracellular enhancement of BMP signaling by LIM-domain protein FHL3 controls spatiotemporal emergence of the neural crest driven by WNT signaling Mansour Alkobtawi, Patrick Pla, Anne H. Monsoro-Burq bioRxiv 711192; doi: https://doi.org/10.1101/711192
^ ^a ^b Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/mcb.20.22.8613-8622.2000. PMC 102166. PMID 11046156.
^ ^a ^b Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (April 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.
^ Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY, Fung KP, Waye MM (2001). "Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. PMID 11135358. S2CID 36346381.
^ Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962.

External links

FHL3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183386 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032643 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8753811-5] Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem Biophys Res Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811.

[pmid10226657-6] Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999). "Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1". Somat Cell Mol Genet. 24 (3): 197–202. doi:10.1023/B:SCAM.0000007122.03392.4b. PMID 10226657. S2CID 40511123.

[entrez-7] "Entrez Gene: FHL3 four and a half LIM domains 3".

[8] Cottle et al., J Cell Sci. 2007 Apr 15;120(Pt 8):1423-35. doi: 10.1242/jcs.004739

[9] Intracellular enhancement of BMP signaling by LIM-domain protein FHL3 controls spatiotemporal emergence of the neural crest driven by WNT signaling Mansour Alkobtawi, Patrick Pla, Anne H. Monsoro-Burq bioRxiv 711192; doi: https://doi.org/10.1101/711192

[pmid11046156-10] Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/mcb.20.22.8613-8622.2000. PMC 102166. PMID 11046156.

[pmid12556451-11] Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (April 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.

[pmid11135358-12] Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY, Fung KP, Waye MM (2001). "Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. PMID 11135358. S2CID 36346381.

[pmid15117962-13] Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962.

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Function

Interactions

References

Further reading

External links